Breast cancers presenting luminal B subtype features show higher discordant human epidermal growth factor receptor 2 results between immunohistochemistry and fluorescence in situ hybridization.

Abstract

The result of FISH is significantly related to prognosis of patients with IHC-negative or IHC-equivocal result. Therefore, FISH should be performed in IHC-equivocal cases. FISH assay might be considered for a selected group of patients with IHC-negative tumors showing luminal B subtype features of ER-positive, grade II/III, and high Ki-67 expression.

Full Text

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Temas

• Adulto
• Neoplasmas De La Mama
• Diferenciacion Celular
• Cell Proliferation
• Distribucion De Chi-cuadrado
• Hembra
• Humanos
• Inmunohistoquimica
• Hibridizacion Fluorescente In Situ
• Kaplan-Meier Estimate
• Middle Aged
• Pronostico
• Modelos De Riesgos Proporcionales
• Receptor Erbb-2
• Receptores Estrogenicos
• Estudios Retrospectivos
• Tasa De Supervivencia
• Marcadores Biologicos De Tumor

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Autores

• Seho Park
• Hyung Seok Park
• Ja Seung Koo
• Woo Ick Yang
• Seung Il Kim
• Byeong-Woo Park

Fecha de publicación

2012-02-06

Revista

Temas de la revista

• Neoplasmas

Idioma

Eng.

Copyright

Cancer

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Referencia de entrega

Cancer. 2012 Feb;118(4):914-23

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