Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in southwest China.

Abstract

A total of 3 SNPs might act as tag SNPs for the entire HMGB1 gene.

The rs2249825 and the haplotype TCG might be used as relevant risk estimate for the development of sepsis and MODS in patients with major trauma.

Full Text

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Temas

• Adulto
• Asian Continental Ancestry Group
• Secuencia De Bases
• China
• Cartilla De Adn
• Hembra
• Predisposicion Genetica A La Enfermedad
• Proteína Hmgb1
• Haplotipos
• Humanos
• Leucocitos
• Desequilibrio De Enlace
• Lipopolisacaridos
• Varón
• Middle Aged
• Insuficiencia De Multiples Organos
• Polimorfismo De Nucleotido Simple
• Factores De Riesgo
• Sepsis
• Heridas Y Traumatismos

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Autores

• Ling Zeng
• An-Qiang Zhang
• Wei Gu
• Ke-Hong Chen
• Dong-Po Jiang
• Lian-Yang Zhang
• Ding-Yuan Du
• Ping Hu
• Su-Na Huang
• Hai-Yan Wang
• Jian-Xin Jiang

Fecha de publicación

2012-02-14

Revista

Temas de la revista

• General Surgery

Idioma

Eng.

Copyright

Surgery

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Chongqing, China.

Referencia de entrega

Surgery. 2012 Mar;151(3):427-36

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