Pleural fluid mesothelin for the differential diagnosis of exudative pleural effusions.

Auteurs :	Carmen Alemán, José Manuel Porcel, Rosa Ma Segura, José Alegre, Aureli Esquerda, Eva Ruiz, Silvia Bielsa, Tomás Fernández de Sevilla
Langue :	Eng.
Date :	2009-10-05
Journal :	Medicina clinica (0025-7753)
Release:	Med Clin (Barc). 2009 Oct;133(12):449-53
Abstract:	BACKGROUND: Malignant mesothelioma (MM) is a highly aggressive tumor that can be difficult to diagnose, resulting in a delayed diagnosis in some cases. Recent studies have reported that determination of soluble mesothelin-related peptides (SMRP) in pleural fluid may be a promising marker for use in the diagnosis of MM. PATIENTS AND METHODS: Pleural fluid SMRP concentration was measured in 68 PATIENTS: 47 had malignant pleural effusions (18 MM and 29 metastatic effusion) and 21 had benign pleural effusion (8 infectious disease and 13 idiopathic effusion). Mann-Whitney analysis was used to compare SMRP values according to the etiology of the effusion. RESULTS: Pleural fluid SMRP concentration was significantly higher in patients with malignant pleural effusion than in those with benign effusion (P=0.02). When malignant pleural effusions were analyzed separately, MM patients had the highest median pleural fluid SMRP concentration, with significant differences as compared to patients with idiopathic pleural effusion. CONCLUSIONS: Soluble mesothelin-related peptide measurement in pleural fluid may aid in the diagnosis of patients presenting with pleural effusion.
Copyright:	Medicina clinica Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain. 29261cal comb.es
Full text:	DOI - Medicina clinica (DOI) Ediciones Doyma, S.L. - HTML (a besoin d'abonnement) Elsevier Science - HTML (a besoin d'abonnement)
Sujets:	adénocarcinome, Biological Markers, Breast Neoplasms, Carcinoma, Small Cell, Diagnosis, Differential, femelle, Hematologic Neoplasms, humains, Lung Neoplasms, mâle, Membrane Glycoproteins, mésothéliome, Ovarian Neoplasms, Pancreatic Neoplasms, Pleural Effusion, Pleural Effusion, Malignant, Prospective Studies, Sensitivity and Specificity, Statistics, Nonparametric