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Role of interleukin-7 in degenerative and inflammatory joint diseases.| Auteurs : | Joel Ag van Roon, Floris Pjg Lafeber | | Langue : | Eng. | | Date : | 27-06-2008 | | Journal : | Arthritis research
(1478-6362)
| | Release: | Arthritis Res Ther. 2008 ;10(2):107 | |
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Abstract:
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ABSTRACT : IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. IL-7 stimulates production of proteases by IL-7 receptor-expressing chondrocytes and enhances cartilage matrix degradation. This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases.
| | Copyright: | Arthritis research
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan, 3584 CX Utrecht, The Netherlands. j.vanroon@umcutrecht.nl. | | Full text: | | | |
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Articles d'autres spécialités : chirurgie maxillo-faciale, Dermatologie, Medecine legale, Médecine interne, Pédiatrie, Immunologie Clinique, Médecine sportive, Radiologie, pharmacologie clinique, Médecine générale, Hygiène et Médecine préventive, Angiologie |
