Pediatric morphea (localized scleroderma): review of 136 patients.

作者:	Stéphanie Christen-Zaech, Miriam D Hakim, F Sule Afsar, Amy S Paller
语言:	Eng.
日期:	2008-08-12
学报:	Journal of the American Academy of Dermatology (1097-6787)
发行:	J Am Acad Dermatol. 2008 Sep;59(3):385-96
摘要:	BACKGROUND: Morphea is an autoimmune inflammatory sclerosing disorder that may cause permanent functional disability and disfigurement. OBJECTIVES: We sought to determine the clinical features of morphea in a large pediatric cohort. METHODS: We conducted a retrospective chart review of 136 pediatric patients with morphea from one center, 1989 to 2006. RESULTS: Most children showed linear morphea, with a disproportionately high number of Caucasian and female patients. Two patients with rapidly progressing generalized or extensive linear morphea and arthralgias developed restrictive pulmonary disease. Initial oral corticosteroid treatment and long-term methotrexate administration stabilized and/or led to disease improvement in most patients with aggressive disease. LIMITATIONS: Retrospective analysis, relatively small sample size, and risk of a selected referral population to the single site are limitations. CONCLUSIONS: These data suggest an increased prevalence of morphea in Caucasian girls, and support methotrexate as treatment for problematic forms. Visceral manifestations rarely occur; the presence of progressive problematic cutaneous disease and arthralgias should trigger closer patient monitoring.
版权:	Journal of the American Academy of Dermatology Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611-2997, USA.
全文:	DOI - Journal of the American Academy of Dermatology (DOI)
科目:	Adolescent, Age of Onset, Antibodies, Antinuclear, Autoimmune Diseases, Child, Child, Preschool, Dermatologic Agents, European Continental Ancestry Group, Female, Humans, Infant, Male, Methotrexate, Prevalence, Retrospective Studies, Risk Factors, Scleroderma, Localized, Scleroderma, Systemic, Sex Factors, Skin